![]() Increasing age, especially after 65 (or after 50 if you have risk factors for atherosclerosis)Ĭomplications of peripheral artery disease caused by atherosclerosis include:.High levels of an amino acid called homocysteine, which increase the risk for coronary artery disease.A family history of peripheral artery disease, heart disease or stroke.Smoking or having diabetes greatly increases the risk of developing peripheral artery disease.Other things that increase the risk of peripheral artery disease include: Less common causes of peripheral artery disease include: When it occurs in the arteries supplying blood to the limbs, it causes peripheral artery disease. It reduces blood flow through the arteries.Ītherosclerosis affects arteries throughout the body. Peripheral artery disease is often caused by a buildup of fatty, cholesterol-containing deposits (plaques) on artery walls. Plaque and blood clots can reduce blood flow through an artery. If a plaque ruptures, a blood clot can form. Plaque can cause an artery to become narrowed or blocked. If there's too much cholesterol in the blood, the cholesterol and other substances may form deposits called plaque. When to see a doctorĬall your health care provider if you have leg pain, numbness or other symptoms of peripheral artery disease. Hanging the legs over the edge of the bed or walking may temporarily relieve the pain. If peripheral artery disease gets worse, pain may occur during rest or when lying down. Hair loss or slower hair growth on the legs.Pain when using the arms, such as aching and cramping when knitting, writing or doing other manual tasks.Sores on the toes, feet or legs that won't heal.Painful cramping in one or both of the hips, thighs or calf muscles after certain activities, such as walking or climbing stairs.No pulse or a weak pulse in the legs or feet.Coldness in the lower leg or foot, especially when compared with the other side.Other peripheral artery disease symptoms may include: Severe leg pain may make it hard to walk or do other types of physical activity. The pain is most commonly felt in the calf. Some people have leg pain when walking (claudication).Ĭlaudication symptoms include muscle pain or cramping in the legs or arms that begins during exercise and ends with rest. Many people with peripheral artery disease have mild or no symptoms.
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